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TPSB2 / Tryptase Beta 2 Antikörper

Sino Biological Inc. liefert TPSB2 / Tryptase Beta 2 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TPSB2 / Tryptase Beta 2 Antikörper lesen Sie bitte: http://www.sinobiological.com/TPSB2-Tryptase-Beta-2-Antibody-g-10150.html

Produkt-Information von TPSB2 / Tryptase Beta 2 Antikörper

Immunogen

Recombinant Human TPSB2 / Tryptase Beta 2 protein (Catalog#10505-H08H)

Antibody Type Mouse Monoclonal Antibody ( Mouse mAb Service Platform )

Clone ID

03

Ig Type

Mouse IgG1

Formulation 0.2 μm filtered solution in PBS with 5% trehalose
Preparation

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TPSB2 / Tryptase Beta 2 (rh TPSB2 / Tryptase Beta 2; Catalog#10505-H08H; NP_077078.5; Met 1-Pro 275). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Usage Guide von TPSB2 / Tryptase Beta 2 Antikörper

Specificity

Human TPSB2 / Tryptase Beta 2

 

No cross-reactivity in ELISA with

Human cell lysate (293 cell line)

Direct ELISA This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human TPSB2. The detection limit for Human TPSB2 is approximately 0.16 ng/well.
Storage This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von TPSB2 / Tryptase Beta 2 Antikörper

Related Areas:

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>TPSB2/Tryptase Beta 2

Immunology>>Innate Immunity>>Mast Cell>>TPSB2/Tryptase Beta 2

Proteins:
Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
TPSB2/Tryptase Beta 2 Human TPSB2 Protein, Recombinant 10505-H08H
Antibodies:
Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human TPSB2/Tryptase Beta 2 ELISA TPSB2 / Tryptase Beta 2 Antibody 10505-MM03

Hintergrund von TPSB2 / Tryptase Beta 2 Anti

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1, and fall into two groups, α and β. β-tryptases appear to be the main isoenzymes expressed in mast cells, whereas α-tryptases predominate in basophils. Tryptase is unique in two respects: it is enzymatically active only as a heparin-stabilized tetramer, and it is resistant to all known endogenous proteinase inhibitors because of the unique arrangement of the active sites. Additionally, tryptase family genes have an intron immediately upstream of the initiator codon which separates the transcription initiation site from protein coding sequence, and this feature is characteristic of tryptases. β-tryptases existing in three isoforms (β1,β2,β3) are released in secretory granules, and have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. It has been reported that β-tryptase selectively cleaves ASM-derived eotaxin and RANTES and abrogates their chemotactic activities.

References

  1. Miller, J.S. et al., 1990, J. Clin. Invest. 86: 864-870.
  2. Pereira, P.J. et al., 1998, Nature. 392: 306-311.
  3. Pallaoro, M.et al., 1999, J. Biol. Chem. 274: 3355-3362.
  4. Pang, L. et al., 2006, J. Immunol. 176: 3788-3795.

Primary Antibody Products

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