TNFAIP8 Protein (His Tag)

15.04.2013

Sino Biological Inc. liefert TNFAIP8 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TNFAIP8 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/TNFAIP8-Protein-Antibody-a-5765.html

Produkt-Information von TNFAIP8 Protein

Synonym	TNFAIP8
Protein Construction	A DNA sequence encoding the mature form of human TNFAIP8 (O95379) (Met1-Ile198) was expressed with a polyhistide tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von TNFAIP8 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: TNFAIP8 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human TNFAIP8 consists of 213 amino acids and predicts a molecular mass of 24.8 KDa. It migrates as an approximately 26 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, 10% glycerol, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von TNFAIP8 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von TNFAIP8 Protein

TNFAIP8 belongs to the TNFAIP8 family. It is expressed at high levels in the fetal liver, lung and kidney while at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle. TNFAIP8 also is expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Meanwhile it is expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. TNFAIP8 acts as a negative mediator of apoptosis and may play a role in tumor progression. It suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.

References

Suzuki Y. et al., 2004, Genome Res. 14 (9): 1711-8.
Rual JF. et al., 2005, Nature. 437 (7062): 1173-8.
Ewing RM. et al., 2007, Mol Syst Biol. 3 (1): 89.

TNFAIP8 related areas, pathways, and other information