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| Immunogen | Recombinant Human TNF-beta / TNFSF1 / Lymphotoxin alpha protein (Catalog#10270-HNAE) |
| Antibody Type | Mouse Monoclonal Antibody ( Mouse mAb Service Platform ) |
| Clone ID | 1H3E1 |
| Ig Type | Mouse IgG1 |
| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TNF-beta / TNFSF1 / Lymphotoxin alpha (rh TNF-beta / TNFSF1 / Lymphotoxin alpha ; Catalog#10270-HNAE; P01374; Leu 35-Leu 205). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Specificity | Human TNF-beta / TNFSF1 / Lymphotoxin alpha |
| No cross-reactivity in ELISA with Human cell lysate (293 cell line) | |
| Western blot | This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human TNFβ in WB. Using a DAB detection system, the detection limit for Human TNFβ is approximately 100 ng/lane under non-reducing conditions and 50 ng/lane under reducing conditions. |
| Direct ELISA | This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human TNFβ. The detection limit for Human TNFβ is approximately 0.31 ng/well. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1 and TNFB, is a secreted protein which belongs to thetumor necrosis factor family. TNFB / TNF-beta / LTA is a highly inducible, secreted, and exists as homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNFB / TNF-beta / LTA binds to TNFRSF3 / LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells. TNFB / TNF-beta / LTA forms heterotrimers with lymphotoxin-betawhich anchors lymphotoxin-alpha to the cell surface. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNFB / TNF-beta / LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in TNFB / TNF-beta / LTA are a cause of susceptibility psoriatic arthritis which is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy.
Sino Biological Inc. liefert TNF-beta / TNFSF1 / Lymphotoxin alpha Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über TNF-beta / TNFSF1 / Lymphotoxin alpha Antikörper lesen Sie bitte: http://www.sinobiological.com/TNF-beta-TNFSF1-Lymphotoxin-alpha-Antibody-g-8715.html
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