TMED1 Protein

07.12.2012

Sino Biological Inc. liefert TMED1 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TMED1 Protein lesen Sie bitte: http://www.sinobiological.com/TMED1-Protein-g-9975.html

Produkt-Information von TMED1 Protein

Synonym	TMED1, IL1RL1L, IL1RL1LG
Protein Construction	A DNA sequence encoding the human TMED1 (Q13445) (Met1-Asn194) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von TMED1 Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: TMED1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 24
Molecular Mass	The recombinant human TMED1 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 412 amino acids and has a predicted molecular mass of 46.2 kDa. The apparent molecular mass of the protein is approximately 57 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von TMED1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von TMED1 Protein

TMED1 is a member of the EMP24/GP25L family. It is widely expressed and contains 1 GOLD domain. TMED1 may play a role in vesicular protein trafficking, mainly in the early secretory pathway. It may act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. TMED1 binds to its receptor IL1RL1 and results in the activation of DNA binding by nuclear factor NF-kappa-B or transcription from the IL8 promoter and most likely requires other proteins to elicit these activities. Dendritic cells from Peyer's patches (but not from spleen) express TMED1 in response to treatment with LPS.

References

Colland F. et al., 2004, Genome Res. 14 (7): 1324-32.
Gerhard DS. et al., 2005, Nature. 437 (7062): 1173-8.
Gerhard DS. et al., 2004, Genome Res. 14 (10B): 2121-7.

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
TMED1	Human	TMED1 Protein, Recombinant	13302-H02H
TMED1	Human	TMED1 Protein, Recombinant	13302-H08H