Thrombopoietin / THPO / TPO Antikörper

29.02.2012

Produkt-Information von Thrombopoietin / THPO / TPO Antikörper

Immunogen	Recombinant Cynomolgus Thrombopoietin / THPO / TPO protein (Catalog#90004-C08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Cynomolgus Thrombopoietin / THPO / TPO (rCynomolgus Thrombopoietin / THPO / TPO; Catalog#90004-C08H; Met 1-Gly 353). Total IgG was purified by Protein A affinity chromatography.

Thrombopoietin / THPO / TPO Antikörper Usage Guide

Specificity	Cynomolgus Thrombopoietin / THPO / TPO
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Cynomolgus TPO in WB.
Direct ELISA	This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Cynomolgus TPO. The detection limit for Cynomolgus TPO is approximately 0.0195 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von Thrombopoietin / THPO / TPO Antikörper

Thrombopoietin (TPO) is a hematopoietic growth factor that is involved in the regulation of platelet production. This cytokine is composed of an amino-terminal erythropoietin-like domain which is the functional domain and a highly glycosylated carboxyl domain that appears to stabilize circulating thrombopoietin. TPO stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. It has been identified that surface c-MPL, the receptor for TPO, binds to the ligand and mediates the action. TPO has multilineage effects in hematopoiesis, not only stimulating megakaryocytopoiesis but also acting in synergy with other cytokines to enhance proliferation and survival of committed erythroid progenitors and primitive hematopoietic stem cells. Mouse TPO is found mainly in the liver, kidney and skeletal muscle.

References

Gurney AL, et al., 1994, Science, 265 (5177): 1445-7.
De Sauvage FJ, et al., 1994, Nature, 369 (6481): 533-8.
Eaton DL,et al., 1995, Curr Opin Hematol, 2 (3): 167-71.
Lok S,et al., 1994, Stem Cells, 12 (6): 586-98.
Drexler HG,et al., 1996, Leukemia, 10 (9): 1405-21.
Miyazaki H,et al., 1999, Int J Hematol, 70 (4): 216-25.

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