Prealbumin / Transthyretin / TTR Antikörper (Antigen Affinität reinig)

29.02.2012

Produkt-Information von Prealbumin / Transthyretin / TTR Antikörper

Immunogen	Recombinant Human Prealbumin / Transthyretin / TTR protein (Catalog#12091-H08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human Prealbumin / Transthyretin / TTR (rh Prealbumin / Transthyretin / TTR; Catalog#12091-H08H; NP_000362.1; Met 1-Glu 147). Prealbumin / Transthyretin / TTR specific IgG was purified by Human Prealbumin / Transthyretin / TTR affinity chromatography.

Prealbumin / Transthyretin / TTR Antikörper Usage Guide

Specificity	Human Prealbumin / Transthyretin / TTR
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TTR in WB. Using a DAB detection system, the detection limit for Human TTR is approximately 8 ng/lane under non-reducing conditions and 2 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TTR. The detection limit for Human TTR is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von Prealbumin / Transthyretin / TTR Antikörper

Transthyretin, also known as ATTR, Prealbumin, TTR and PALB, is a secreted and cytoplasm protein which belongs to thetransthyretin family. Transthyretin (TTR / PALB) is detected in serum and cerebrospinal fluid (at protein level). It is highly expressed in choroid plexus epithelial cells. It is also detected in retina pigment epithelium and liver. Each monomer of Transthyretin (TTR / PALB) has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel. Defects in TTR / PALB are the cause of amyloidosis type 1 (AMYL1) which is a hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system.

References

Herbert J. et al., 1986, Neurology 36: 900-11.
Getz R.K. et al., 1999, Exp. Eye Res. 68: 629-36.
Naylor H.M. et al., 1999, Biochemistry 38: 2647-53.
Jiang X. et al., 2001, Biochemistry 40:11442-52.
Sebastiao M.P. et al., 2001, J. Mol. Biol. 306: 733-44.
Gales L. et al., 2008, Biochim. Biophys. Acta 1784: 512-7.

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