Thioredoxin-2 / TXN2 Antikörper

12.03.2012

Produkt-Information von Thioredoxin-2 / TXN2 Antikörper

Immunogen	Recombinant Human Thioredoxin-2 / TXN2 protein (Catalog#12557-H07E)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human Thioredoxin-2 / TXN2 (rh Thioredoxin-2 / TXN2; Catalog#12557-H07E; Q99757; Thr 60-Gly 166). Total IgG was purified by Protein A affinity chromatography.

Thioredoxin-2 / TXN2 Antikörper Usage Guide

Specificity	Human Thioredoxin-2 / TXN2
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human TXN2 in WB.
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human TXN2. The detection limit for Human TXN2 is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von Thioredoxin-2 / TXN2 Antikörper

Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains onethioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. Thioredoxin-2 / TXN2 has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Thioredoxin-2 / TXN2 could be involved in the resistance to anti-tumor agents. It possesses a dithiol-reducing activity. Thioredoxin-2 / TXN2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis. Mammalian Thioredoxin-2 / TXN2 is a mitochondrial isoform of highly evolutionary conserved thioredoxins. Thioredoxins are small ubiquitous protein-disulfide oxidoreductases implicated in a large variety of biological functions.

References

Chen Y., et al., 2002, J. Biol. Chem. 277: 33242-8.
Smeets A., et al., 2005, Protein Sci. 14: 2610-21.
Wen,S. et al., 2009, Am J Med Genet A149A (2): 155-60.
Choudhary C., et al., 2009, Science 325: 834-40.

Sino Biological Inc. liefert Thioredoxin-2 / TXN2 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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