CD20 / MS4A1 Antikörper (Antigen Affinität reinigt)

12.03.2012

Produkt-Information von CD20 / MS4A1 Antikörper

Immunogen	Recombinant Ferret CD20 / MS4A1 protein (Catalog#60004-F08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Ferret CD20 / MS4A1 (rF CD20 / MS4A1; Catalog#60004-F08H; Glu 213-Pro 297). CD20 / MS4A1 specific IgG was purified by Ferret CD20 / MS4A1 affinity chromatography.

CD20 / MS4A1 Antikörper Usage Guide

Specificity	Ferret CD20 / MS4A1
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Ferret CD20 in WB. Using a DAB detection system, the detection limit for Ferret CD20 is approximately 0.5 ng/lane under non-reducing conditions and 1 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Ferret CD20. The detection limit for Ferret CD20 is approximately 0.00245 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von CD20 / MS4A1 Antikörper

Verwandte Bereiche:

Proteine:

Antikörper:

Hintergrund von CD20 / MS4A1 Antikörper

Ferret B-lymphocyte antigen CD20, also known as B-lymphocyte surface antigen B1, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1 and MS4A1, is a multi-pass membrane protein which belongs to theMS4A family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed on all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is found on B-cell lymphomas, hairy cell leukemia, B-cell chronic lymphocytic leukemia, and melanoma cancer stem cells. CD20 / MS4A1 is the target of the monoclonal antibodies (mAb) rituximab, Ibritumomab tiuxetan, and tositumomab, which are all active agents in the treatment of all B cell lymphomas and leukemias. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen.

References

Tedder TF, et al.,1988, Proc Natl Acad Sci USA85 (1): 208-12.
Cragg MS, et al., 2005, Curr. Dir. Autoimmun.8: 140-74.
Fang D, et al., 2005, Cancer Res.65 (20): 9328-37.
Teeling J.L., et al., 2006, J. Immunol. 177: 362-371.

Sino Biological Inc. liefert CD20 / MS4A1 Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CD20 / MS4A1 Antikörper (Antigen Affinität reinigt) lesen Sie bitte: http://www.sinobiological.com/CD20-MS4A1--Antibody-g-8259.html