TBCB Protein (His Tag)

25.03.2013

Sino Biological Inc. liefert TBCB Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TBCB Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/TBCB-Protein-Antibody-a-5746.html

Produkt-Information von TBCB Protein

Synonym	TBCB, CG22, CKAP1
Protein Construction	A DNA sequence encoding the mature form of human TBCB (Q99426) (Met1-Ile244) was expressed with a polyhistide tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von TBCB Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: TBCB protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human TBCB consists of 259 amino acids and predicts a molecular mass of 29.2 KDa. It migrates as an approximately 33-37 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von TBCB Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von TBCB Protein

Tubulin-folding cofactor B, also known as TBCB, is a member of the TBCB family. It contains 1 CAP-Gly domain and can be detected in most tissues. Tubulin-folding cofactor B is highly expressed in brain. It is broadly distributed throughout the neonate brain but restricted mainly to ependymary cells in the adult brain where it is concentrated in the cilia. Tubulin-folding cofactor B binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway. The cytoskeleton is composed of 3 structural elements: actin filaments, microtubules, and intermediate filaments. Tubulin-folding cofactor B is involved in regulation of tubulin heterodimer dissociation. It may function as a negative regulator of axonal growth.

References

Feingold EA. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903.
Tian G. et al., 1997, J Cell Biol. 138 (4): 821-32.
Wolz W. et al., 1997, Cytogenet Cell Genet. 72 (2-3): 215-6.