Sus scrofa (Pig) Transferrin / TF Protein

Produkt-Information von Transferrin / TF Protein

QC Testing von Transferrin / TF Protein

Purity	> 88 % as determined by SDS-PAGE	SDS-PAGE: Transferrin / TF protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 22
Molecular Mass	The secreted recombinant pig (Sus scrofa) transferrin/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 935 amino acids and has a predicted molecular mass of 103 kDa. It migrates as an approximately 100-110 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von Transferrin / TF Protein

Verwandte Produkte & Themen von Transferrin / TF Protein

Beschreibung von Transferrin / TF Protein

The melanotransferrin (MTf) molecule, also called CD228 or p97, has been widely described as a melanoma specific molecule. MTf is found at high levels in melanoma cells and previous studies have shown that MTf can bind Fe. MTf has a high level of sequence homology to transferrin (Tf) and lactoferrin, but is unusual because it predominantly occurs as a membrane bound, glycosylphosphatidylinositol (GPI) anchored molecule, but can also occur as a soluble form. The iron-binding properties of melanotransferrin, the tumour-associated antigen p97, have been investigated by many aspects and the results show that, in contrast to other transferrins, melanotransferrin binds only one Fe3+ ion per molecule. The binding properties of its N-terminal site are similar to other transferrins, but its C-terminal site does not bind iron at all. The differences can be related to specific amino acid changes in the C-terminal site. In clinical, The protein melanotransferrin (MTf) is associated with the brain lesions of Alzheimer's disease (AD) and is a potential marker of the disorder. Serum MTf is a candidate marker of AD, even in the early stage when clinical diagnosis is most uncertain.

References

1. Richardson DR. 2000, Eur J Biochem. 267 (5): 1290-8.
2. Kim DK. et al., 2001, Neuropsychopharmacology. 25 (1): 84-90.
3. Rothenberger S. et al., 1996, Brain Res. 712 (1): 117-21.
4. Baker EN. et al., 1992, FEBS Lett. 298 (2-3): 215-8.

Sino Biological Inc. liefert Sus scrofa (Pig) Transferrin / TF Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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