SERPINB3 / SCCA-1 Protein (His Tag)

28.03.2012

Produkt-Information von FTH1 Protein

Synonym	OK/SW-cl.84, FHC, FTH, FTHL6, PIG15, PLIF
Protein Construction	A DNA sequence encoding the human FTH1 (P02794) (Met 1-Ser183) was expressed and purified.
Source	Human
Expression Host	E.coli

FTH1 Protein QC Testing

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: FTH1 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met 1
Molecular Mass	The recombinant human FTH1 consists of 183 amino acids and has a calculated molecular mass of 21.2KDa as estimated in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.5 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

FTH1 Protein Usage Guide

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von FTH1 Protein

FTH1(ferritin, heavy polypeptide 1) is the heavy subunit of ferritin. Ferritin is a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion. The protein is produced by almost all living organisms, including algae, bacteria and higher plants, and animals. In humans, it acts as a buffer against iron deficiency and iron overload. The amount of ferritin stored reflects the amount of iron stored. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Deficiency of ferritin proteins is associated with several neurodegenerative diseases. FTH1 stores iron in a soluble, non-toxic, readily available form. It is important for iron homeostasis. It has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. It also plays a role in delivery of iron to cells and mediates iron uptake in capsule cells of the developing kidney.

References

Hentze MW. et al., 1986, Proc Natl Acad Sci. 83 (19): 7226-30.
Rual. et al., 2005, Nature (England). 437 (7062): 1173-8.
Stelzl. et al., 2005, Cell (United States). 122 (6): 957-968.

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