Serglycin / SRGN Protein (His Tag)

18.04.2013

Sino Biological Inc. liefert Serglycin / SRGN Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Serglycin / SRGN Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/Serglycin-SRGN-Protein-g-11575.html

Produkt-Information von Serglycin / SRGN Protein

Synonym	SRGN, PRG, PRG1
Protein Construction	A DNA sequence encoding the human SRGN (CAA34900.1) (Met1-Leu158) was expressed with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von Serglycin / SRGN Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: SRGN protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Tyr 28
Molecular Mass	The recombinant human SRGN consists of 142 amino acids and predicts a molecular mass of 16.1 KDa. It migrates as an approximately 57 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von Serglycin / SRGN Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von Serglycin / SRGN Protein

SRGN is known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of various hematopoietic cells has a protease-resistant peptide core, and is vital for neutralizing hydrolytic enzymes. SRGN is associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. It is required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. SRGN also plays a role in localizing neutrophil elastase in azurophil granules of neutrophils.

References

Hatton MN. et al., 1985, Biochem J. 230 (3): 817-20.
Schick BP. et al., 1995, J Cell Physiol. 165 (1): 96-106.
Kato S. et al., 1995, Gene. 150 (2): 243-50.