SCN3B Protein

29.03.2012

Produkt-Information von SCN3B Protein

Synonym	HSA243396, SCNB3
Protein Construction	A DNA sequence encoding the human SCN3B (Q9NY72) extracellular domain (Met 1- Glu 159) was fused with the Fc region of human IgG1 at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von SCN3B Protein

Purity	> 96 % as determined by SDS-PAGE	SDS-PAGE: SCN3B protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Phe 23
Molecular Mass	The recombinant human SCN3B/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 378 amino acids and has a predicted molecular mass of 42.5 kDa. The apparent molecular mass of the reduced monomer is approximately 50-55 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

SCN3B Protein Usage Guide

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von SCN3B Protein

SCN3B (sodium channel, voltage-gated, type III, beta ,human IgG1-Fc chimera) belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family. It contains 1 Ig-like C2-type (immunoglobulin-like) domain. SCN3B modulates channel gating kinetics; causes unique persistent sodium currents; inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. Defects in SCN3B are the cause of Brugada syndrome type 7. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram. It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.

References

Morgan K. et al., 2000, Proc Natl Acad Sci. 97 (5): 2308-13.
Hartley JL. et al. Genome Res. 10 (11): 1788-95.
Hirosawa M. et al., 2000, DNA Res. 6 (5): 329-36.

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