SAA4 Protein (GST Tag)

08.10.2012

Produkt-Information von SAA4 Protein

Synonym	SAA4, CSAA
Protein Construction	A DNA sequence encoding the mature form of human SAA4 (P35542) (Glu19-Tyr130) was fused with the GST tag at the N-terminus.
Source	Human
Expression Host	E.coli

SAA4 Protein QC Testing

Purity	> 93 % as determined by SDS-PAGE	SDS-PAGE: SAA4 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human SAA4 /GST chimera consists of 344 amino acids and has a predicted molecular mass of 39.8KDa. It migrates as an approximately 36 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, 0.5% Triton X-100, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von SAA4 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von SAA4 Protein

SAA4 belongs to the SAA family. Members of this family are apolipoproteins of high density lipoprotein (HDL). They can be separated into two distinct groups. First group (SAA1, SAA2, and SAA3) consists of acute phase reactant whose expression level increase in the blood in a response to trauma, infection, inflammation, and neoplasia. The second distinct group is comprised by SAA4 and SAA5 which exist as the minor apolipoproteins on HDL, but this group of SAA constitutes more than 90% of all the SAA during homeostasis, and it is thought to play a role in the normal functioning of the HDL particle. SAA4 is constitutively expressed only in humans and mice. The physiological function of SAA4 is unknown.As an apolipoprotein of the HDL complex, SAA4 functions as a major acute phase reactant. SAA4 mRNA and protein occurrence in macrophage derived foam cells of coronary and carotid arteries implied a specific role of human SAA4 during inflammation including atherosclerosis.

References

Davila S. et al., 2010, Genes Immun. 11(3):232-8.
Murphy CL. et al., 2009, Amyloid. 16(2):84-8.
Prakash T. et al., 2010, PLoS One. 5(10):e13284.

Sino Biological Inc. liefert SAA4 Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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