FAM19A2 Protein

29.09.2012

Produkt-Information von FAM19A2 Protein

Synonym	FAM19A2, TAFA2
Protein Construction	A DNA sequence encoding the human FAM19A2(Q8N3H0-1) (Ala31-His131 ) was expressed, fused with the Fc region of human IgG1 at the N-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von FAM19A2 Protein

Purity	> 79 % as determined by SDS-PAGE	SDS-PAGE: FAM19A2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant human FAM19A2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 361 amino acids and has a predicted molecular mass of 39.7 kDa. The apparent molecular mass of the protein is approximately 43 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von FAM19A2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von FAM19A2 Protein

FAM19A2 is a member of the FAM19/TAFA family. FAM19A2 gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. They are chemokine-like proteins. Their biological functions remain to be determined, but there are a few tentative hypotheses. They may modulate immune responses in the CNS by functioning as brain specific chemokines, and may act with other chemokines to optimize the recruitment and activity of immune cells in the CNS. They also may represent a novel class of neurokines that act as regulators of immune nervous cells. Finally, they may control axonal sprouting following brain injury. Human FAM19A2 is 97% aa identical to mouse FAM19A2 and is expressed in the central nervous system (CNS), colon, heart, lung, spleen, kidney, and thymus.

References

Parsa A. et al., 2011, Clin Transl Sci. 4(1):17-23.
Rose JE. et al., 2010, Mol Med. 16(7-8):247-53.
Trynka G. et al., 2009, Gut. 58(8):1078-83.

Sino Biological Inc. liefert FAM19A2 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über FAM19A2 Protein lesen Sie bitte: http://www.sinobiological.com/FAM19A2-Protein-g-9330.html