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| Immunogen | Recombinant Human RRM2B / P53R2 protein (Catalog#13150-H07E) |
| Antibody Type | Mouse Monoclonal Antibody ( Mouse mAb Service Platform ) |
| Clone ID | 04 |
| Ig Type | Mouse IgG1 |
| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RRM2B / P53R2 (rh RRM2B / P53R2; Catalog#13150-H07E; Q7LG56-1; Met 1-Phe 351). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatograph. |
| Specificity | Human RRM2B / P53R2 |
| No cross-reactivity in ELISA with E.coli cell lysate | |
| Western blot | This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human RRM2B in WB. |
| Direct ELISA | This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human RRM2B. The detection limit for Human RRM2B is approximately 0.039 ng/well. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Enzyme>>Lipid Metabolism Enzymes>>RRM2B
Cardiovascular>>Lipid Metabolism>>Lipid Metabolism Enzymes>>RRM2B
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| RRM2B | Human | RRM2B / P53R2 Protein,Recombinant | 13150-H07E |
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human RRM2B | WB, ELISA | RRM2B / P53R2 Antibody | 13150-MM04 |
| Human RRM2B | ELISA, IHC-P | RRM2B / P53R2 Antibody (Antigen Affinity Purified) | 13150-RP02 |
Ribonucleoside reductase subunit M2B (also known as RRM2B or p53R2) is an enzyme belonging to the iron-dependent ribonucleotide reductase (RNR) enzyme family which is essential for DNA synthesis. Ribonucleotide reductase (RNR) is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides and plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair. Using in vivo 32P-orthophosphate labeling, it has been observed that 32P can be incorporated into RRM2B/p53R2 induced by UV irradiation, suggesting that p53R2 is a phosphorylated protein. It is hypothesized that p53R2 activity can be regulated at the posttranslational level in response to DNA damage. p53R2 has previously been shown to be essential for the maintenance of mtDNA copy number and its candidacy for tumor suppression has been evaluated in several mutational analyses of different cancer types. However, the contribution of p53R2 to the DNA damage response has been questioned because its transcriptional induction upon DNA damage is not rapid enough for prompt DNA repair. Instead, ATM-mediated phosphorylation has been suggested to regulate the DNA repair activity of p53R2 posttranslationally. In addition, a defect in p53R2 can induce a mild muscle disease of adult onset through disturbance of mitochondrial homeostasis but that this defect does not appear to be oncogenic.
Sino Biological Inc. liefert RRM2B / P53R2 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über RRM2B / P53R2 Antikörper lesen Sie bitte: http://www.sinobiological.com/RRM2B-P53R2-Antibody-g-9507.html
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