Rat TNFSF9 Protein

Produkt-Information von TNFSF9 Protein

TNFSF9 Protein QC Testing

Purity	> 96 % as determined by SDS-PAGE	SDS-PAGE: TNFSF9 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant rat TNFSF9 comprises 463 amino acids and predicts a molecular mass of 50.9 kDa. The apparent molecular mass of  the recombinant protein is approximately 61 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von TNFSF9 Protein

Verwandte Produkte & Themen von TNFSF9 Protein

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>4-1BBL/CD137L/TNFSF9

Immunology>>Cytokine & Receptor>>TNF Superfamily>>4-1BBL/CD137L/TNFSF9

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>4-1BBL/CD137L/TNFSF9

Beschreibung von TNFSF9 Protein

4-1BB ligand (4-1BBL), also known as TNFSF9, is a member of the tumor necrosis factor (TNF) superfamily (TNFSF), and interacts with 4-1BB (CDw137) expressed on activated T cells and delivers a costimulatory signal for T cell activation and growth. Mouse 4-1BBL is a 309 amino acid (aa) residues protein with an 82 aa N-terminal cytoplasmic domain, a 21 aa transmembrane domain and a 206 aa C-terminal extracellular domain. The extracellular domain of 4-1BBL has a tertiary structure similar to that other TNFSF members, but shares only low aa sequence homology (14 - 16%). Murine 4-1BBL shares 36% aa sequence identity with its human counterpart which is detected in both T and B cells of human peripheral blood. 4-1BB ligand interacts with 4-1BB and co-stimulates the latter to secrete cytokines and to proliferate, and also this interaction modulates the effector CD4+ T cell-driven immune response and cytokine production in colitis without affecting regulatory T cell function.

References

1. Goodwin RG. et al., 1993, Eur J Immunol. 23: 2631-41.
2. Alderson MR. et al., 1994, Eur J Immunol. 24: 2219-27.
3. Zhou Z. et al., 1995, Immunol Lett. 45 (1-2): 67-73.
4. Futagawa T. et al., 2002, Int Immunol. 14 (3): 275-86.
5. Yoshida H. et al., 2003, Cancer Immunol Immunother. 52 (2): 97-106.
6. Maerten P. et al., 2006, Clin Exp Immunol. 143 (2): 228-36.

Sino Biological Inc. liefert Rat TNFSF9 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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