Rat TNFSF12 Protein

08.03.2013

Sino Biological Inc. liefert Rat TNFSF12 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat TNFSF12 Protein lesen Sie bitte: http://www.sinobiological.com/TNFSF12-Protein-g-10563.html

Produkt-Information von TNFSF12 Protein

Synonym	TNFSF12, Prmt2
Protein Construction	A DNA sequence encoding the rat TNFSF12 (Arg105-His249) was expressed with Fc region of human IgG1 at the N-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von TNFSF12 Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: TNFSF12 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant rat TNFSF12 comprises 405 amino acids and predicts a molecular mass of 44.4 kDa. The apparent molecular mass of the recombinant protein is approximately 49 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von TNFSF12 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von TNFSF12 Protein

TNFSF12 is a member of the tumor necrosis factor (TNF) ligand family. Iit is a cytokine and also a ligand for the FN14/TWEAKR receptor. It binds to FN14 and possibly also to TNRFSF12/APO3. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. TNFSF12 is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. It also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.

References

Wiley SR. et al., 2004, Cytokine Growth Factor Rev. 14 (3-4): 241-9.
Campbell. S et al., 2006, Front Biosci. 9: 2273-84.
Lynch CN. et al., 1999, J Biol Chem. 274 (13): 8455-9.

Cytokine