Rat TNFRSF11A Protein (His Tag)

Beschreibung von TNFRSF11A Protein

QC Testing von TNFRSF11A Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: TNFRSF11A protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Val 31
Molecular Mass	The secreted recombinant rat TNFRSF11A comprises 194 amino acids and predicts a molecular mass of 21.5 kDa. The apparent molecular mass of the rat TNFRSF11A is approximately 32 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von TNFRSF11A Protein

Verwandte Produkte Themen von TNFRSF11A Protein

Beschreibung von TNFRSF11A Protein

TNFRSF11A, also known as CD265, contains 4 TNFR-Cys repeats and belongs to the TNF-receptor superfamily. TNFRSF11A has an ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. TNFRSF11A can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It is also an essential mediator for osteoclast and lymph node development. Defects in TNFRSF11A are the cause of familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.

References

1. Darnay B G. et al., 1998, J Biol Chem. 273 (32): 20551-5.
2. Darnay B G. et al., 1999, J Biol Chem. 274 (12): 7724-31.
3. Galibert L. et al., 1998, J Biol Chem. 273 (51): 34120-7.

Sino Biological Inc. liefert Rat TNFRSF11A Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat TNFRSF11A Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/TNFRSF11A-Protein-g-9134.html