KDR / VEGFR2 / CD309 Protein (GST Tag)

Produkt-Information von KDR / VEGFR2 / CD309 Protein

QC Testing von KDR / VEGFR2 / CD309 Protein

Purity	> 78 % as determined by SDS-PAGE	SDS-PAGE: KDR / VEGFR2 / CD309 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human KDR /GST chimera consists of 787 amino acids and has a calculated molecular mass of 89.3 kDa. The recombinant protein migrates as an approximately 110 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 50mM Tris,100mM NaCl,pH 8.0,10%gly, 2mM GSH. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von KDR / VEGFR2 / CD309 Protein

Verwandte Produkte & Themen von KDR / VEGFR2 / CD309 Protein

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>VEGFR2/Flk-1/CD309

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>VEGFR2/Flk-1/CD309

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hematopoietic Stem Cell Marker>>VEGFR2/Flk-1/CD309

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Hemangioblast Marker>>VEGFR2/Flk-1/CD309

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>VEGFR2/Flk-1/CD309

Cancer>>Growth factor & Receptor>>VEGF & Receptor>>VEGFR2/Flk-1/CD309

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>VEGFR2/Flk-1/CD309

Immunology>>Cluster of Differentiation>>Hematopoietic Stem Cell CD Marker>>VEGFR2/Flk-1/CD309

Beschreibung von KDR / VEGFR2 / CD309 Protein

Vascular endothelial cell growth factor (VEGF), also known as vascular permeability factor, is an endothelial cell mitogen, which stimulates angiogenesis by binding to specific receptors (VEGFRs) on the surface of vascular endothelial cells. The VEGF ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. All the three receptors for VEGF, VEGFR1~3, belong to CSF-1/PDGF receptor subfamily of receptor tyrosine kinase superfamily (RTKs), and contains seven Ig-like C2-type domains in the ECD, as well as a intracellular protein kinase domain. VEGFR2, also called as KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. The adaptor protein SHB has been shown to interact with VEGFR2 in receptor tyrosine kinase signaling. In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.

References

1. Terman BI. et al., 1992, Biochem Biophys Res Commun. 187: 1579-86.
2. McTigue MA. et al., 1999, Structure. 7: 319-30.
3. Patterson C. et al., 1995, J Biol Chem. 270: 23111-8.
4. Holmqvist K. et al., 2004, J Biol Chem. 279: 22267-75.

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