Rat TDGF1 / CRGF Protein

21.01.2012

TDGF1 / CRGF Protein Product Information

Synonym :	FGFR-4
Protein Construction:	A DNA sequence encoding the rat TDGF1 (XP_001056317.2) (Met 1-Cys 143) was fused with the Fc region of human IgG₁ at the C-terminus.
Source:	Rat
Expression Host:	Human Cells

TDGF1 / CRGF Protein QC Testing

Purity:	>90 % as determined by SDS-PAGE.	SDS-PAGE: TDGF1 / CRGF protein
Endotoxin:	< 1.0 EU per μg of the protein as determined by the LAL method
Stability:	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal:	Phe 17
Molecular Mass:	The recombinant rat TDGF1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 368 amino acids and predicts a molecular mass of 41 kDa. The apparent molecular mass of the rat TDGF1/Fc monomer is approximately 45 kDa in SDS-PAGE under reducing conditions.
Formulation:	Lyophilized from sterile PBS , pH 7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

TDGF1 / CRGF Protein Usage Guide

Storage:	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TDGF1 / CRGF Protein Related Products & Topics

Related Areas:

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Stem Cell Marker>>Cripto/TDGF1

Neuroscience>>Axon Guidance>>TGF-beta Family>>Cripto/TDGF1

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>TGF-beta Family>>Cripto/TDGF1

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>Cripto/TDGF1

Proteins:

Cripto/TDGF1

Human

Cripto/TDGF1 Protein, Recombinant

10908-H08H

Antibodies:

TDGF1 / CRGF Protein Description

Teratocarcinoma-derived growth factor 1, also known as Epidermal growth factor-like cripto protein CR1, CRGF, and TDGF1, is a cell membrane which contains one EGF-like domain. In humans, TDGF1 is highly expressed in germ cell tumors and in colon and mammary carcinomas. TDGF1 is a member of the epidermal growth factor-cripto FRL1 cryptic protein family and is involved in the activation of several different signaling pathways during embryonic development and cellular transformation. TDGF1 regulates the activation of several signaling pathways and controls cellular transformation in embryonic status. Patients with high TDGF1 expression were statistically susceptible to a recurrence of the disease, and showed poorer disease-free survival than those with low expression. TDGF1 is a predictive marker for metachronous metastasis in colorectal cancer (CRC) patients. It is preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. TDGF1 plays a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

References

Liguori G. et al., 1996, Mamm Genome. 7 (5): 344-8.
De la Cruz. et al., 2002, J M Hum Genet. 110 (5): 422-8.
Liguori G. et al., 1997, Mamm Genome. 8 (7): 502-5.
Miyoshi N. et al., 2010, Int J Oncol. 36 (3): 563-8.

Sino Biological Inc. liefert Rat TDGF1 / CRGF Protein mit höherer Qualität und günstigen Kosten im Vergleich mit anderen globalen Lieferanten.

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