Rat SEMA4D / Semaphorin 4D Protein (His Tag)

Sino Biological Inc. liefert Rat SEMA4D / Semaphorin 4D Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat SEMA4D / Semaphorin 4D Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/SEMA4D-Semaphorin-4D-Protein-g-9960.html

Produkt-Information von SEMA4D / Semaphorin-4D Protein

QC Testing von SEMA4D / Semaphorin-4D Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: SEMA4D protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Phe 24
Molecular Mass	The recombinant rat SEMA4D comprises 700 amino acids and predicts a molecular mass of 77.8 kDa. The apparent molecular mass of  the recombinant protein is approximately 96 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von SEMA4D / Semaphorin-4D Protein

Verwandte Produkte & Themen von SEMA4D / Semaphorin-4D Protein

Neuroscience>>Axon Guidance>>Semaphorin & Related Molecules>>Semaphorin 4D/SEMA4D/CD100

Immunology>>Cluster of Differentiation>> rel="external"Semaphorin 4D/SEMA4D/CD100

Beschreibung von SEMA4D / Semaphorin-4D Protein

Semaphorin-4D, also known as SEMA4D and CD100, is a single-pass type I  membrane protein which belongs to the semaphorin family. Semaphorin-4D / SEMA4D contains one Ig-like C2-type (immunoglobulin-like) domain, one PSI domain and one Sema domain. Semaphorin-4D / SEMA4D is strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. Semaphorin-4D / SEMA4D may play a functional role in the immune system, as well as in the nervous system. Induces B-cells to aggregate and improves their viability. Semaphorin-4D / SEMA4D is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin-B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system. In the immune system, Semaphorin-4D / SEMA4D binds CD72 to activate B cells and dendritic cells. It is involved in oligodendrogenesis during development and during recovery from ischemic injury.

References

1. Masuda,K. et al., 2004, Genes Cells. 9 (9):821-9.
2. Duran-Struuck R. et al., 2007, Biol Blood Marrow Transplant. 13 (11): 1294-303.
3. Taniguchi Y. et al., 2009, J Neurosci Res. 87 (13): 2833-41.
4. Ch'ng E S. et al., 2010, Mol Cancer. 9 :251.