Rat PROCR / EPCR Protein (His Tag)

19.03.2013

Sino Biological Inc. liefert Rat PROCR / EPCR Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat PROCR / EPCR Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/Epcr-PROCR-Protein-a-2649.html

Produkt-Information von PROCR / EPCR Protein

Synonym	PROCR
Protein Construction	A DNA sequence encoding the rat PROCR (Met1-Ser213) was expressed with a polyhistidine tag at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von PROCR / EPCR Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: PROCR protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Asn 21
Molecular Mass	The recombinant rat PROCR comprises 204 amino acids and predicts a molecular mass of 23.2 kDa. The apparent molecular mass of the recombinant protein is approximately 33-37 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von PROCR / EPCR Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von PROCR / EPCR Protein

Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells(cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occur when it does not. When still bound to EPCR, activated protein C performs its cytoprotective effects.

References

Nicolaes GA. et al., 2003, Semin Vasc Med. 3 (1): 33-46.
Esmon CT. 2003, Chest. 124 (3): 26-32.
Mosnier LO. et al., 2007, Blood. 109: 3161-3172.