Rat LGALS8 / Galectin-8 Protein (GST Tag)

Product Information von LGALS8 / Galectin-8 Protein

QC Testing von LGALS8 / Galectin-8 Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: LGALS8 / Galectin-8 protein
Bio-activity	Measured by its ability to agglutinate human red blood cells. The ED50 for this effect is typically 0.05-0.3 μg/mL.
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant rat LGALS8/GST chimera consists of 548 amino acids and has a predicted molecular mass of 63.2 kDa. It migrates as a 55KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS ,10%glycerol,1mM DTT, pH8.0 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von LGALS8 / Galectin-8 Protein

Verwandte Produkte & Themen von LGALS8 / Galectin-8 Protein

Immunology>>Adhesion Molecule>>Lectin>>Galectin-8/LGALS8

Beschreibung von LGALS8 / Galectin-8 Protein

Galectin-8, also known as Gal-8, Po66 carbohydrate-binding protein, Prostate carcinoma tumor antigen 1, PCTA-1 and LGALS8, is a member of the galectin family. Galectin-8 / LGALS8 was discovered in prostate cancer cells and has been studied extensively in the last few years. Various studies showed that galectin-8 is widely expressed in tumor tissues as well as in normal tissues. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. Galectin-8 / LGALS8 is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. The level of galectin-8 expression may correlate with the malignancy of human colon cancers and the degree of differentiation of lung squamous cell carcinomas and neuro-endocrine tumors. The differences in Galectin-8 / LGALS8 expression levels between normal and tumor tissues have been used as a guide for the selection of strategies for the prevention and treatment of lung squamous cell carcinoma. Galectin-4, Galectin-8 represents a subfamily of galectins consisting of a tandem repeat of structurally different carbohydrate recognition domains within a single polypeptide chain.

References

1. Hadari YR. et al., 1995, J Biol Chem. 270 (7): 3447-53.
2. Bidon N. et al., 2001, Int J Mol Med. 8 (3): 245-50.
3. Nishi N. et al., 2003, Glycobiology. 13 (11): 7 55-63.
4. Bidon-Wagner N. et al., 2004, Glycoconj J. 19 (7-9): 557-63.

Sino Biological Inc. liefert Rat LGALS8 / Galectin-8 Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat LGALS8 / Galectin-8 Protein (GST Tag) lesen Sie bitte: http://www.sinobiological.com/LGALS8-Galectin-8-Protein-g-8803.html