Rat LAMP1 / CD107a Protein

20.09.2012

Produkt-Information von LAMP1 / CD107a Protein

Synonym	LAMP1
Protein Construction	A DNA sequence encoding the Rat LAMP1 (P14562) (Met1-Asn371) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von LAMP1 / CD107a Protein

Purity	>92 % as determined by SDS-PAGE	SDS-PAGE: LAMP1 / CD107a protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 22
Molecular Mass	The recombinant Rat LAMP1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 591 amino acids and has a predicted molecular mass of 65.1 kDa. The apparent molecular mass of the protein is approximately 123 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von LAMP1 / CD107a Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

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Related Areas:

Cancer>>Cancer Stem Cell (CSC)>>LAMP-1/CD107a

Immunology>>Innate Immunity>>Lysosomal Enzyme>>LAMP-1/CD107a

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>LAMP-1/CD107a

Immunology>>Cluster of Differentiation>>Other>>LAMP-1/CD107a

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
LAMP-1/CD107a	Human	LAMP-1/CD107a Protein, Recombinant	11215-H08H
LAMP-1/CD107a	Rat	LAMP1 / CD107a Protein, Recombinant	80226-R02H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human LAMP-1/CD107a	WB, ELISA	Mouse Monoclonal Antibody	11215-MM07
Human LAMP-1/CD107a	WB, FCM	LAMP-1 / CD107a / LAMP1 Antibody ( FITC )	11215-MM07-F
Human LAMP-1/CD107a	WB, ELISA	LAMP-1/CD107a Antibody, Rabbit MAb	11215-R107
Human LAMP-1/CD107a	WB, ELISA	Rabbit Polyclonal Antibody	11215-RP01
Human LAMP-1/CD107a	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11215-RP02

Beschreibung von LAMP1 / CD107a Protein

Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein which belongs to the LAMP family. CD107a is expressed largely in the endosome-lysosome membranes of cells, but is also found on the plasma membrane (1-2% of total LAMP1). LAMP1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed LAMP1 serves as a therapeutic agent for some cancers, as well as a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. LAMP2, also known as CD107b, may also play a role in tumor cell metastasis and functions in the protection, maintenance, and adhesion of the lysosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.

References

Schleutker J. et al., 1992, Hum Genet. 88 (1): 95-7.
Kannan K.et al., 1996, Cell Immunol. 171 (1):10-9.
Chang MH. et al., 2003, J Biol Regul Homeost Agents. 16 (2): 147-51.
Parkinson-Lawrence EJ. et al., 2005, Cell Immunol. 236 (1-2): 161-6.

Sino Biological Inc. liefert Rat LAMP1 / CD107a Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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