Rat F3 / Tissue factor Protein (His Tag)

Sino Biological Inc. liefert Rat F3 / Tissue factor Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat F3 / Tissue factor Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/F3-Tissue-factor-Protein-g-10201.html

Produkt-Information von F3 / Tissue factor Protein

QC Testing von F3 / Tissue factor Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: F3 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 29
Molecular Mass	The recombinant rat F3 comprises 235 amino acids and predicts a molecular mass of 27.2 kDa. The apparent molecular mass of  the recombinant protein is approximately 47-52  kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von F3 / Tissue factor Protein

Verwandte Produkte & Themen von F3 / Tissue factor Protein

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>Coagulation Factor III/Tissue Factor/CD142

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>Coagulation Factor III/Tissue Factor/CD142

Immunology>>Innate Immunity>>Coagulation>>Coagulation Factor III/Tissue Factor/CD142

Immunology>>Cluster of Differentiation>>Other>>Coagulation Factor III/Tissue Factor/CD142

Beschreibung von F3 / Tissue factor Protein

Tissue factor, also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Because of its essential role in hemostasis, Tissue factor plays a role in pathology associated with hemostasis, triggering the coagulation system in many thrombotic diseases and the coagulopathies associated with sepsis and other forms of disseminated intravascular coagulation. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. Tissue factor is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes.

References

1. Lwaleed BA. et al., 2001, J Pathol. 193 (1): 3-12.
2. Morrissey JH. 2004, Int J Hematol. 79 (2): 103-8.
3. Panasiuk A. et al., 2007, Blood Coagul Fibrinolysis. 18 (8): 739-44.
4. Kinev AV. et al., 2008, Lupus. 17 (10): 952-8.