Rat CD164 / Endolyn Protein

Sino Biological Inc. liefert Rat CD164 / Endolyn Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat CD164 / Endolyn Protein lesen Sie bitte: http://www.sinobiological.com/CD164-Endolyn-Protein-g-10200.html

Produkt-Information von CD164 / Endolyn Protein

QC Testing von CD164 / Endolyn Protein

Purity	> (84.8+14.7)% as determined by SDS-PAGE	SDS-PAGE: CD164 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 24
Molecular Mass	The recombinant rat CD164/Fc is a disulfide-linked homodimer. The reduced monomer comprises 378 amino acids and has a predicted molecular mass of 41.3 kDa. The apparent molecular mass of the protein is approximately 90 and 35 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD164 / Endolyn Protein

Verwandte Produkte & Themen von CD164 / Endolyn Protein

Immunology>>Adhesion Molecule>>Other>>CD164

Immunology>>Cluster of Differentiation>>CD164

Beschreibung von CD164 / Endolyn Protein

Sialomucin core protein 24, also known as Endolyn, Multi-glycosylated core protein 24, MGC-24 and CD164, is a single-pass type I membrane and secreted protein which belongs to the CD164 family. Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play two key but opposing roles: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to the stroma and by negatively regulating CD34+CD38 (lo/-) cell proliferation. CD164 functions as an adhesion receptor. It is known to function as a receptor that regulates stem cell localization to the bone marrow. CD164 modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. CD164 promotes myogenesis by enhancing CXCR4-dependent cell motility. It positively regulates myoblast migration and promotes myoblast fusion into myotubes. CD164 may participate in the localization of prostate cancer cells to the marrow CD164 may play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cell.

References

1. Watt SM, et al., 1998, Blood. 92 (3): 849-66.
2. Zannettino A.C.W., et al., 1998, Blood 92:2613-2628.
3. Havens A.M., et al., 2006, BMC Cancer 6:195-195.
4. Forde S., et al., 2007, Blood 109:1825-1833.