Rat DSC2 / Desmocollin-2 Protein (His Tag)

21.03.2013

Sino Biological Inc. liefert Rat DSC2 / Desmocollin-2 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat DSC2 / Desmocollin-2 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/DSC2-Protein-a-1530.html

Produkt-Information von DSC2 / Desmocollin-2 Protein

Synonym	DSC2
Protein Construction	A DNA sequence encoding the rat DSC2 (Q3T1K6)(Met1-Pro694) was expressed with a polyhistidine tag at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von DSC2 / Desmocollin-2 Protein

Purity	(41%+45) % as determined by SDS-PAGE	SDS-PAGE: DSC2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Cys 29
Molecular Mass	The recombinant rat DSC2 comprises 677 amino acids and predicts a molecular mass of 76.1 kDa. The apparent molecular mass of the recombinant protein is approximately 76 and 91 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von DSC2 / Desmocollin-2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von DSC2 / Desmocollin-2 Protein

Desmocollin-2, also known as Cadherin family member 2, Desmocollin-3, Desmosomal glycoprotein II, Desmosomal glycoprotein III, DSC2 and CDHF2, is a single-pass type I membrane protein which contains five cadherin domains. The desmocollins are members of the desmosomal cadherin family of cell-cell adhesion molecules. They are essential constituents of desmosomes, intercellular junctions that play a critical role in the maintenance of tissue integrity in epithelia and cardiac muscle. In humans, three desmocollins (DSC1, DSC2 and DSC3) have been described. DSC2 / CDHF2 is component of intercellular desmosome junctions. It is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSC2 / CDHF2 may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia type 11 (ARVD11) also known as arrhythmogenic right ventricular cardiomyopathy 11 (ARVC11). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death.

References

Liu T. et al., 2005, J Proteome Res. 4: 2070-80.
Khan K. et al., 2006, Br J Cancer. 95 (10): 1367-70.
Ramachandran P. et al., 2006, J Proteome Res. 5: 1493-503.
Syrris P. et al., 2006, Am J Hum Genet. 79: 978-84.
Beffagna G. et al., 2007, BMC Med Genet. 8: 65.