Rat CXCL16 / SRPSOX Protein (His Tag)

16.04.2012

Produtk-Information von CXCL16 / SRPSOX Protein

Synonym	CXCL16
Protein Construction	A DNA sequence encoding the rat CXCL16 (Q6AXU5) extracellular domain (Met 1-Ala 198) was expressed, fused with a polyhistidine tag at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von CXCL16 / SRPSOX Protein

Purity	> 98 % as determined by SDS-PAGE	SDS-PAGE: CXCL16 / SRPSOX protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Asn 27
Molecular Mass	The recombinant rat CXCL16 comprises 183 amino acids and predicts a molecular mass of 20.4 kDa. The apparent molecular mass of the rat CXCL16 is approximately 42 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CXCL16 / SRPSOX Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CXCL16 / SRPSOX Protein

C-X-C motif chemokine 16, also known as Small-inducible cytokine B16, SR-PSOX, and CXCL16, is a single-pass type I membrane protein which belongs to the intercrine alpha (chemokine CxC) family. It is expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. It is weakly expressed in heart and liver and no expression in brain and bone marrow. CXCL16 is expressed on the surface of APCs including subsets of CD19(+) B cells and CD14(+) monocyte / macrophages, and functional CXCL16 is also shed from macrophages. CXCL16 is an alpha (CXC) chemokine but also has characteristics of CC chemokines and a structure similar to fractalkine (neurotactin) in having a transmembrane region and a chemokine domain suspended by a mucin-like stalk. CXCL16 may function in promoting interactions between DCs and CD8 T cells and in guiding T cell movements in the splenic red pulp. CXCL16 was also found in the thymic medulla and in some nonlymphoid tissues, indicating roles in thymocyte development and effector T cell trafficking.

References

Matloubian M. et al., 2000, Nat Immunol. 1 (4): 298-304.
Wilbanks A. et al., 2001, J Immunol. 166 (8): 5145-54.
Abel S. et al., 2004, J Immunol. 172 (10): 6362-72.

Sino Biological Inc. liefert Rat CXCL16 / SRPSOX Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat CXCL16 / SRPSOX Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/CXCL16-SRPSOX-Protein-g-8733.html

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
CXCL16	Mouse	CXCL16/SR-PSOX Protein, Recombinant	50142-M08H