Rat CSF2RB Protein (Cytokine)

28.03.2013

Sino Biological Inc. liefert Rat CSF2RB Protein (Cytokine) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat CSF2RB Protein (Cytokine) lesen Sie bitte: http://www.sinobiological.com/CD131-CSF2RB-IL3RB-IL5RB-Protein-Antibody-a-726.html

Produkt-Information von CSF2RB Protein

Synonym	CSF2Rb, Csf2rb1
Protein Construction	A DNA sequence encoding the rat CSF2Rb (Met1-Trp440) was expressed with the Fc region of human IgG1 at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von CSF2RB Protein

Purity	(24.0+69.6 )% as determined by SDS-PAGE	SDS-PAGE: CSF2RB protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His 23
Molecular Mass	The recombinant rat CSF2Rb/Fc is a disulfide-linked homodimer. The reduced monomer comprises 659 amino acids and has a predicted molecular mass of 75.1 kDa. The apparent molecular mass of the protein is approximately 123 and 89 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von CSF2RB Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CSF2RB Protein

Colony stimulating factor 2 receptor, beta, low-affinity, also known as Cytokine receptor common subunit beta, CSF2RB, CDw131, and CD131, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 4 subfamily. It is a 897 amino acid protein which the sequence is further processed into a mature form. The cytokine receptor is a heterodimer of an alpha and a beta subunit, and this beta subunit (CD131) is also the common and high affinity receptor to the interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. It contains two fibronectin type-III domains. The WSXWS motif of CD131 appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of CD131 is required for JAK interaction and/or activation.

References

Mulhern TD. et al., 2000, J Mol Biol. 297: 989-1001.
Carr PD. et al., 2001, Cell. 104: 291-300.
Carr PD. et al., 2006, Acta Crystallogr. F 62: 509-13.
Selleri S. et al., 2008, J Transl Med. 6 : 17.

Cytokine