Rat CLP1 / COLEC12 Protein (His Tag)

17.09.2012

Produkt-Information von CLP1 / COLEC12 Protein

Synonym	Clp1, Nsr2, COLEC12
Protein Construction	A DNA sequence encoding the mature form of rat COLEC12 (Q4V885) (Ala101-Leu742) was expressed ,with a polyhistide tag at the N-terminus.
Source	Rat
Expression Host	Baculovirus-Insect cells

CLP1 / COLEC12 Protein QC Testing

Purity	> 99 % as determined by SDS-PAGE	SDS-PAGE: CLP1 / COLEC12 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant ratCOLEC12 consists of 658 amino acids and predicts a molecular mass of 72.4 KDa. It migrates as an approximately 90 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 20mM Tris, 500mM NaCl, pH8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CLP1 / COLEC12 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CLP1 / COLEC12 Protein

CLP1, also known as COLEC12, belongs to the Clp1 family. Clp1 subfamily. It is a component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with the cleavage factor NAB4/CFIB and the cleavage and polyadenylation factor (CPF) complex. As a scavenger receptor, CLP1 displays several functions associated with host defense. It promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. CLP1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. CLP1 contains 1 C-type lectin domain and 3 collagen-like domains. It is strongly expressed in placenta and moderately expressed in heart, skeletal muscle, small intestine and lung.

References

Ramirez A. et al., 2008, RNA. 14 (9): 1737-45.
Danielsen JM. et al., 2011, Mol Cell Proteomics. 10 (3): M110.003590.
Kim W. et al., 2011, Mol Cell. 44 (2): 325-40.

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