Rat ALK-2 / ACVR1 / ALK2 Protein

Sino Biological Inc. liefert Rat ALK-2 / ACVR1 / ALK2 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von ALK-2 / ACVR1 / ALK2 Protein

QC Testing von ALK-2 / ACVR1 / ALK2 Protein

Purity	> 90% as determined by SDS-PAGE	SDS-PAGE: ALK-2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met 21
Molecular Mass	The recombinant rat ACVR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 344 amino acids and has a predicted molecular mass of 38.5 kDa. The apparent molecular mass of the protein is approximately 43 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von ALK-2 / ACVR1 / ALK2 Protein

Verwandte Produkte & Themen von ALK-2 / ACVR1 / ALK2 Protein

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>Activin/Inhibitin>>ALK-2/ACVR1

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>ALK-2/ACVR1

Beschreibung von ALK-2 / ACVR1 / ALK2 Protein

Cytokines and hormones belonging to the transforming growth factor beta (TGFβ) superfamily such as the activin, anti-müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal, are involved in a variety of physiological processes including growth, cell differentiation, homeostasis, osteogenesis, and apoptosis. They initiate signaling through heteromeric complexes of a type I  and a type I I serine/threonine kinase receptor. The two type receptors are type I transmembrane proteins and are distinguished by the presence of a glycine/serine-rich juxta-membrane domain found in the type I receptors. Type II receptors are required for binding ligands and recruitment of type I receptors which then form stable complexes, and type I receptors are essential for signaling transduction. ALK2, also termed as ACVR1, ActRI, SKR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or IIB. In addition, ALK2 is also identified as a BMP type I receptor. ACVR1 has been demonstrated to form complex with either the BMP-2/7-bound BMPR-II or ACVR2A/ACVR2B and transduce signals to downstream components R-SMADs. Recombinant soluble ALK2 does not bind activin. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

References

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4. Shore EM. et al., 2006, Nature Genetics. 38: 525-7.
5. Renlund N. et al., 2007, J Endocrinology. 195: 95-103.