Profilin 2 / PFN2 Protein (His Tag)

19.06.2013

Sino Biological Inc. liefert Profilin 2 / PFN2 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Profilin 2 / PFN2 Protein (His Tag) lesen Sie bitte:http://www.sinobiological.com/Profilin-2-PFN2-Protein-Antibody-a-6233.html

Produkt-Information von Profilin 2 / PFN2 Protein

Synonym	PFN2
Protein Construction	A DNA sequence encoding the human PFN2 (AAH18049.1) (Met1-Phe140) was expressed with a polyhistidine tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von Profilin 2 / PFN2 Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: Profilin 2 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human PFN2 consists of 155 amino acids and predicts a molecular mass of 16.9 KDa. It migrates as an approximately 16 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 50mM Tris, 10% Glycerol, pH 8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von Profilin 2 / PFN2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von Profilin 2 / PFN2 Protein

Profilin 2, also known as PFN2, is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver. Profilin 2 binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. Profilin 2 is thought to regulate actin polymerization in response to extracellular signals. It inhibits the formation of IP3 and DG by binding to PIP2.

References

Da Silva. et al., 2003, J Cell Biol. 162 (7): 1267-79.
Honore B. et al., 1993, FEBS Lett. 330 (2): 151-5.
Joensuu T. et al., 1997, Genomics. 38 (3): 255-63.