PON3 Protein (His Tag)

Serum paraoxonase / lactonase 3, also known as PON3, is a secreted protein which belongs to the paraoxonase family. The paraoxonase (PON) gene family in humans has three members, PON1, PON2, and PON3, which are known to be involved in oxidative stress-associated processes such as dyslipidemia, diabetes and coronary heart disease. Although PON3 is the least studied paraoxonase, findings have shown that it can significantly reduce atherosclerotic lesion formation and obesity in PON3 transgenic mice. Enzymatic characterization of the purified PONs has revealed them to be lactonases/lactonizing enzymes, with some overlapping substrates, but also to have distinctive substrate specificities. All three PONs metabolized very efficiently 5-hydroxy-eicosatetraenoic acid 1,5-lactone and 4-hydroxy-docosahexaenoic acid, which are products of both enzymatic and nonenzymatic oxidation of arachidonic acid and docosahexaenoic acid, respectively, and may represent the PONs' endogenous substrates. PON3 has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. It rapidly hydrolyzes lactones such as statin prodrugs. PON3 hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. PON3 is also involved in obesity-related disorders.

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