Mouse ST6GALNAC2 Protein (His Tag)

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2, also known as STHM or ST6GALNAC2, is a protein belonging to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. STHM / ST6GALNAC2 is a typeⅡ membrane protein localized in the Golgi network and catalyzes 2,6-sialylation of the Tn antigen. The protein is highly expressed in lactating mammary gland and adult testis and lower levels in kidney. Disregulation of the encoding gene is involved in synthesizing a cancer vaccine and in pathogenesis of IgA nephropathy, a common kidney disease that occurs when antibody IgA accumulates in kidneys. Aberrant O-galactosylation of IgA1 molecules plays a role in the development and progression of IgA nephropathy (IgAN). Genetic interactions of C1GALT1 and ST6GALNAC2 variants influence IgA1

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