PDGFRa / CD140a Protein (GST Tag)

Produkt-Information von PDGFRa / CD140a Protein

QC Testing von PDGFRa / CD140a Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: PDGFRa protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human PDGFRA /GST chimera consists of 776 amino acids and has a calculated molecular mass of 89.2 kDa. The recombinant protein migrates as an approximately 92 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 20mM Tris, 500mM NaCl, pH7.4, 10%gly, 3mM DTT. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von PDGFRa / CD140a Protein

Verwandte Produkte & Themen von PDGFRa / CD140a Protein

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>PDGFRA/CD140a

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>PDGFRA/CD140a

Stem Cell>>Neural Stem Cell (NSC)>>Neural Stem Cell Markers>>PDGFRA/CD140a

Stem Cell>>Neural Stem Cell (NSC)>>Glial Cell Markers>>PDGFRA/CD140a

Cancer>>Growth factor & Receptor>>PDGF & Receptor>>PDGFRA/CD140a

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>PDGFRA/CD140a

Immunology>>Cluster of Differentiation>>Other>>PDGFRA/CD140a

Beschreibung von PDGFRa / CD140a Protein

PDGFRα, also known as CD140a, together with the structurally homolog protein PDGFRβ (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin -like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRα is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRβ dose not bind PDGF-AA. PDGF binding induces the receptor homo- and hetero-dimerization as well as activation of the receptor, and subsequently activates c-Src tyrosine kinase which relays signals to PI 3 kinase and MAPK cascades. PDGFRα thus plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGF Rα acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development.

References

1. Matsui T. et al., 1989, Science. 243: 800-4.
2. Yokote K. et al., 1996, J Biol Chem. 271: 5101-511.
3. Choudhury GG. et al., 2000, Kidney Int. 57: 908-17.
4. Brennan J. et al., 2003, Genes & Dev. 17: 800-10.
5. Choudhury GG. et al., 2006, Cell Signal. 18: 1854-64.

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