IGFBP2 Protein

12.10.2012

Produkt-Information von IGFBP2 Protein

Synonym	IGFBP2
Protein Construction	A DNA sequence encoding the Cynomolgus IGFBP2 (F6YKM5) (Met1-Gln324) was expressed, fused with a polyhistidine tag at the C-terminus.
Source	Cynomolgus
Expression Host	Human Cells

QC Testing von IGFBP2 Protein

Purity	> 67 % as determined by SDS-PAGE	SDS-PAGE: IGFBP2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 38
Molecular Mass	The recombinant Cynomolgus IGFBP2 is a disulfide-linked homodimer. The reduced monomer comprises 300 amino acids and has a calculated molecular mass of 32.8 KDa. The apparent molecular mass of Cynomolgus IGFBP2 heterodimer is approximately 37 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IGFBP2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von IGFBP2 Protein

IGFBP-2, also known as IGFBP2, is a insulin-like growth factor-binding protein (IGFBP). IGFBPs play an integral role in modifying insulin-like growth factor (IGF) actions in a wide variety of cell types. There are six members in this family. They are structurally related but encoded by distinct genes. IGFBPs have a high affinity for IGFs. Some members of the IGFBP family have been consistently shown to inhibit IGF actions by preventing them from gaining access to the IGF receptors, while others potentiate IGF actions by facilitating the ligand-receptor interaction. IGFBP-2 contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. It inhibits IGF-mediated growth and developmental rates. IGFBP-2 is overexpressed in many malignancies and is often correlated with an increasingly malignant status of the tumor, pointing to a potential involvement of IGFBP-2 in tumorigenesis.

References

Han VK. et al., 1996, J Clin Endocrinol Metab. 81 (7): 2680-93.
Binkert C. et al., 1989, EMBO J. 8 (9): 2497-502.
Wolf E. et al., 2000, Pediatr Nephrol. 14 (7): 572-8.

Sino Biological Inc. liefert IGFBP2 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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