PDGFRA / CD140a Antikörper

PDGFRα, also known as CD140a, together with the structurally homolog protein PDGFRβ (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRα is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRβ dose not bind PDGF-AA. PDGF binding induces the receptor homo- and hetero-dimerization as well as activation of the receptor, and subsequently activates c-Src tyrosine kinase which relays signals to PI 3 kinase and MAPK cascades. PDGFRα thus plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGF Rα acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development.

1. Matsui, T. et al., 1989, Science. 243: 800-804.
2. Yokote, K. et al., 1996, J. Biol. Chem. 271: 5101-5111.
3. Choudhury, G.G. et al., 2000, Kidney. Int. 57: 908-917.
4. Brennan, J. et al., 2003, Genes & Dev. 17: 800-810.
5. Choudhury, G.G. et al., 2006, Cell. Signal. 18: 1854-18.