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| Immunogen | Recombinant Human IFNGR1 / CD119 protein (Catalog#10338-H08H) |
| Antibody Type | Mouse Monoclonal Antibody ( Mouse mAb Service Platform ) |
| Clone ID | 9B1G4D1 |
| Ig Type | Mouse IgG1 |
| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IFNGR1 / CD119 (rh IFNGR1 / CD119; Catalog#10338-H08H; NP_000407.1; Met 1-Gly 245). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Specificity | Human IFNGR1 / CD119 |
| No cross-reactivity in ELISA with Mouse IFNGR1 Human IL10Rb Human cell lysate (293 cell line) | |
| Western blot | This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human IFNgR1 in WB. Using a DAB detection system, the detection limit for Human IFNgR1 is approximately 1 ng/lane under non-reducing conditions and reducing conditions. |
| Direct ELISA | This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human IFNgR1. The detection limit for Human IFNgR1 is 0.00975 ng/well. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
The protein IFN-γR1 (IFNGR1) is the ligand-binding chain (alpha) of the high-affinity interferon gamma receptor complex which is a heterodimer of IFN-γ R1 (IFN-γ Rα) and IFN-γ R2 (IFN-γ Rβ). IFN-γ R1 is necessary and sufficient for IFN-γ binding and receptor internalization, whereas IFN-γ R2 is required for IFN-γ signal transduction, but does not bind IFN-γ by itself. IFN-γ R1 is constitutively expressed in most cell types and soluble IFN-γ R1 has been detected in biological fluids. Human IFN-γ R1 cDNA encodes a 499 aa residue protein consisting of a 17 aa signal peptide, a 228 aa extracellular domain, a 23 aa transmembrane domain, and a 221 aa intracellular domain. Upon binding to IFN-γ receptor via its C-terminus, the type II interferon IFN gamma triggers multiple intracellular signalling processes including prevention of viral replication, inhibition of cell growth, modulation of cell differentiation, and induction of growth arrest at mid-G1 in different mammary carcinoma cell lines. A genetic variation or deficiency in IFN-γR1 is associated with susceptibility to Helicobacter pylori infection or mycobacterial disease.
Sino Biological Inc. liefert IFNGR1 / CD119 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über IFNGR1 / CD119 Antikörper lesen Sie bitte: http://www.sinobiological.com/IFNGR1-CD119-Antibody-g-8705.html
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