PCSK9 Antikörper

03.09.2012

Produkt-Information von PCSK9 Antikörper

Immunogen	Recombinant Rat PCSK9 protein (Catalog#80005-R08H)
Antibody Type	Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID	03
Ig Type	Mouse IgG1
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat PCSK9 (rR PCSK9; Catalog#80005-R08H; NP_954862.2; Met 1-Gln 691). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Usage Guide von PCSK9 Antikörper

Specificity	Rat PCSK9
	Has cross-reactivity in ELISA with Mouse PCSK9 No cross-reactivity in ELISA with Human PCSK1 Human PCSK9 Rhesus PCSK9 Human cell lysate (293 cell line)
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Rat PCSK9 in WB.
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Rat PCSK9. The detection limit for Rat PCSK9 is approximately 1.25 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von PCSK9 Antikörper

Related Areas:

Enzyme>>Protease & Regulator>>Serine Protease & Regulator>>PCSK9

Enzyme>>Lipid Metabolism Enzymes>>PCSK9

Cardiovascular>>Lipid Metabolism>>Lipid Metabolism Enzymes>>PCSK9

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
PCSK9	Human	PCSK9 protein, Recombinant	10594-H08H
PCSK9	Mouse	PCSK9 protein, Recombinant	50251-M08H
PCSK9	Rat	PCSK9 protein, Recombinant	80005-R08H
PCSK9	Rhesus	PCSK9 protein, Recombinant	11054-C08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human PCSK9	WB, ELISA	Mouse Monoclonal Antibody	10594-MM01
Human PCSK9	WB	Rabbit Monoclonal Antibody	10594-RM03
Human PCSK9	WB, ELISA	Rabbit Polyclonal Antibody	10594-RP02
Human PCSK9	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10594-RP04
Mouse PCSK9	WB, ELISA	PCSK9 Antibody, Rabbit PAb	50251-RP01
Mouse PCSK9	WB, ELISA	PCSK9 Antibody, Rabbit PAb (Antigen Affinity Purified)	50251-RP02
Mouse PCSK9	WB, ELISA	PCSK9 Antibody, Rabbit MAb	50251-R106
Rat PCSK9	WB, ELISA	PCSK9 Antibody	80005-MM03
Rat PCSK9	WB, ELISA	PCSK9 Antibody, Rabbit PAb	80005-RP01
Rat PCSK9	WB, ELISA	PCSK9 Antibody, Rabbit PAb (Antigen Affinity Purified)	80005-RP02

Hintergrund von PCSK9 Antikörper

Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), is a newly identified human secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the generation of an active proteinase with a broad alkaline pH optimum and no apparent calcium requirement for activity. PCSK9 is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. PCSK9 is able to bind directly to the LDLR through its epidermal growth factor-like repeat A (EGF-A) binding domain, and induces and accelerates LDLR internalization and degradation. Accordingly, PCSK9 contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with autosomal dominant hypercholesterolemia characterized by increased LDL cholesterol level, which is a risk factor for coronary heart disease.

References

Sseidah, N.G. et al., 2003, Proc. Natl. Acad. Sci. USA. 100: 928-933.
Beyer, T.P. et al., 2007, J. Lipid. Res. 48: 1488-1498.
Shan, L. et al., 2008, Biochem. Biophys. Res. Commun. 375: 69-73.
Benjannet, S. et al., 2005, J. Biol. Chem. 279: 48865-48875.
Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.

Sino Biological Inc. liefert PCSK9 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über PCSK9 Antikörper lesen Sie bitte: http://www.sinobiological.com/PCSK9-Antibody-g-9513.html