IL-1R1 / CD121a Antikörper

03.09.2012

Produkt-Information von IL-1R1 / CD121a Antikörper

Immunogen	Recombinant Rat IL-1R1 / CD121a protein (Catalog#80028-R08H)
Antibody Type	Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
Clone ID	08
Ig Type	Mouse IgG1
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat IL-1R1 / CD121a (rR IL-1R1 / CD121a; Catalog#80028-R08H; NP_037255.3; Met 1-Lys 352). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Usage Guide von IL-1R1 / CD121a Antikörper

Specificity	Rat IL-1R1 / CD121a
	No cross-reactivity in ELISA with Human cell lysate (293 cell line)
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Rat IL1R1 in WB.
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Rat IL1R1. The detection limit for Rat IL1R1 is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Related Areas:

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>IL-1R1/CD121a

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1R1/CD121a

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-1 Superfamily and IL-1R/TLR Family>>IL-1R1/CD121a

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Other>>IL-1R1/CD121a

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>IL-1R1/CD121a

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>IL-1R1/CD121a

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
IL-1R1/CD121a	Human	IL-1R1/Fc Protein, Recombinant	10126-H02H
IL-1R1/CD121a	Human	IL-1R1 Protein, Recombinant	10126-H08H
IL-1R1/CD121a	Mouse	IL-1R1 Protein, Recombinant	50807-M08H
IL-1R1/CD121a	Mouse	IL1R1 / CD121a Protein, Recombinant	50807-M02H
IL-1R1/CD121a	Rat	IL-1R1 Protein, Recombinant	80028-R06H
IL-1R1/CD121a	Rat	IL-1R1 Protein, Recombinant	80028-R08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human IL-1R1/CD121a	WB, ELISA	Mouse Monoclonal Antibody	10126-MM10
Human IL-1R1/CD121a	WB, ELISA	Rabbit Polyclonal Antibody	10126-RP01
Human IL-1R1/CD121a	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10126-RP02
Rat IL-1R1/CD121a	WB, ELISA	IL-1R1 / CD121a Antibody	80028-MM08
Rat IL-1R1/CD121a	WB, ELISA	IL-1R1 / CD121a Antibody (Antigen Affinity Purified)	80028-RP02

Hintergrund von IL-1R1 / CD121a Antikörper

Interleukin 1 receptor, type I (IL1R1), also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor that belongs to the IL-1 receptor family. IL1R1 is a receptor for both interleukin alpha (IL1A) and interleukin beta (IL1B), and also associates with interleukin-1 receptor antagonist protein (IL-1RA). There are two distinct types of receptors that bind the pleiotropic cytokines IL1A and IL1B: the type I is an 80 kDa transmembrane protein expressed predominantly by T cells, fibroblasts, and endothelial cells and appears to mediate all the known IL-1 biological functions. However, the type II receptor is a 68 kDa transmembrane protein with a short cytoplamic domain and serves as a decoy for IL-1. IL1R1 structurally consists of three C2-type Ig-like domains and one TIR domain. As important mediators involved in many immune and inflammatory responses, the agonists IL1A and IL1B bind to IL1R1, leading to the signal transduction and activation of NF-kappa-B. Formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2 is indepensible for the signaling processes. Recombinant soluble form of IL1R1 is thus a potent antagonist of IL-1 function.

References

Reddy, S. A. et al.,1997, J. Biol. Chem. 272: 29167-29173.
Huang, J. et al.,1997, Proc. Natl. Acad. Sci. USA.94: 12829-12832.
Vigers, G. P.A. et al., 1997, Nature. 386: 190-194.
Schreuder, H. et al., 1997, Nature. 386: 194-200.
Vigers, G.P.A. et al., 2000, J. Biol. Chem. 275: 36927-36933.

Sino Biological Inc. liefert IL-1R1 / CD121a Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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