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| Immunogen | Recombinant Human PARP-1 / PARP protein (Catalog#11040-H08B) |
| Antibody Type | Mouse Monoclonal Antibody ( Mouse mAb Service Platform ) |
| Clone ID | 3H2C10E2 |
| Ig Type |
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| Formulation | 0.2 μm filtered solution in PBS with 5% trehalose |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PARP-1 / PARP (rh PARP-1 / PARP; Catalog#11040-H08B; NP_001609.2; Met 1-Trp 1014). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Specificity | Human PARP-1 / PARP | ||||
| Immunochemistry | IHC-P: 10-30 μg/mL
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| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃.Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| PARP-1/PARP | Human | PARP-1/PARP Protein, Recombinant | 11040-H08B |
| PARP-1/PARP | Mouse | PARP1 / PARP-1 Protein, Recombinant | 50753-M07B |
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human PARP-1/PARP | IHC-P | PARP-1 / PARP Antibody | 11040-MM01 |
| Human PARP-1/PARP | WB, ELISA | PARP-1/PARP Antibody, Rabbit PAb | 11040-RP01 |
| Human PARP-1/PARP | WB, ELISA | PARP-1/PARP Antibody, Rabbit PAb (Antigen Affinity Purified) | 11040-RP02 |
Poly (ADP-ribose) polymerase 1 (PRAP1), also known as NAD (+) ADP-ribosyltransferase 1 (ADPRT), is a chromatin-associated enzyme which modifies various nuclear proteins by poly (ADP-ribosyl)ation. The ADP-D-ribosyl group of NAD+ is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. The poly (ADP-ribosyl)ation modification is critical for a wide range of processes, including DNA repair, regulation of chromosome structure, transcriptional regulation, mitosis and apoptosis. PARP1 is demonstrateed to mediate the poly (ADP-ribose) ation of APLF (aprataxin PNK-like factor) and CHFR (checkpoint protein with FHA and RING domains), two representative proteins involved in the DNA damage response and checkpoint regulation. Further, It has been suggested that DNA-dependent protein kinase (DNA-PK), another component of DNA repair, suppresses PARP activity, probably through direct binding and/or sequestration of DNA-ends which serve as an important stimulator for both enzymes. PARP1 inhibitors is thus proposed as a targeted cancer therapy for recombination deficient cancers, such as BRCA2 tumors.
Sino Biological Inc. liefert PARP-1 / PARP Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.
Weitere Informationen über PARP-1 / PARP Antikörper lesen Sie bitte: http://www.sinobiological.com/PARP-1-PARP-Antibody-g-8784.html
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