NRN1L / Cpg15-2 / Neuritin 1-like Protein

19.06.2013

Sino Biological Inc. liefert NRN1L / Cpg15-2 / Neuritin 1-like Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über NRN1L / Cpg15-2 / Neuritin 1-like Protein lesen Sie bitte:http://www.sinobiological.com/NRN1L- neuritin-1-like -Cpg15-2-Protein-Antibody-a-6227.html

Produkt-Information von NRN1L / Cpg15-2 / Neuritin 1-like Protein

Synonym	NRN1L
Protein Construction	A DNA sequence encoding the human NRN1L (Q496H8) (Met1-Thr138) was expressed with the Fc region of mouse IgG1 at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von NRN1L / Cpg15-2 / Neuritin 1-like Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: NRN1L protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 36
Molecular Mass	The recombinant human NRN1L/mFc comprises 337 amino acids and has a predicted molecular mass of 37.6 kDa. The apparent molecular mass of the monomer is approximately 38 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von NRN1L / Cpg15-2 / Neuritin 1-like Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von NRN1L / Cpg15-2 / Neuritin 1-like Protein

NRN1L, also known as neuritin 1-like and Cpg15-2, belongs to the neuritin family. Neuritin is a GPI-anchored protein that promotes neurite outgrowth and branching of neuritic processes in primary hippocampal and cortical cells. Neuritin expression also enhances the development of motor neuron axon arbors by promoting neuromuscular synaptogenesis and by stimulating the addition of new axon branches. Neuritin is induced by neuronal activity and by the neurotrophins, BDNF and NT3. NRN1L contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. In vitro assays demonstrated that NRN1L promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis.

References

Strausberg RL. et al., 2002, Proc Natl Acad Sci. 99 (26): 16899-903.
Clark HF. et al., 2003, Genome Res. 13 (10): 2265-70.
Fujino T. et al., 2008, J Comp Neurol. 507 (5): 1831-45.