NRG4 Protein

28.03.2012

Produkt-Information von NRG4 Protein

Synonym	HRG4
Protein Construction	A DNA sequence encoding the human NRG4 (Q8WWG1) extracellular domain (Pro 2-Phe 62) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminus.
Source	Human
Expression Host	E.coli

NRG4 Protein QC Testing

Purity	> 92 % as determined by SDS-PAGE	SDS-PAGE: NRG4 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly
Molecular Mass	The recombinant human NRG4 consists of 63 amino acids and has a calculated molecular mass of 6.7 KDa as estimated in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of 50mM Tris, 50mM NaCl; pH 7.2 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

NRG4 Protein Usage Guide

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von NRG4 Protein

NRG4 is one of the four structurally-related proteins that are part of the EGF family of proteins. These proteins have diverse functions in the development of the nervous system and play multiple essential roles in vertebrate embryogenesis. In advanced bladder cancer, NRG4 is frequently failed to be expressed while increased NRG4 expression correlates to better survival. NRG4(neuregulin 4) is a member of the neuregulin protein family. In general, members of this family bind to and activate the erbB family of receptor tyrosine kinases erbB2 (HER2), erbB3 (HER3), and erbB4 (HER4), functioning both as heterodimers and homodimers. NRG4 is a low affinity ligand for the ERBB4 tyrosine kinase receptor. It concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. However, it does not bind to the ERBB1, ERBB2 and ERBB3 receptors.

References

Strausberg RL. et al., 2002, Proc Nat Acad Sci. 99 (26): 16899-903.
Harari D. et al., 1999, Oncogene. 18 (17): 2681-9.
Memon AA. et al., 2004, Br J Cancer. 91 (12): 2034-41.

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