NKG2A / CD159A / KLRC1 Protein (His Tag)

11.09.2012

Produkt-Information von NKG2A / CD159A / KLRC1 Protein

Synonym	KLRC1, NKG2A
Protein Construction	A DNA sequence encoding the mature form of human KLRC1(NP_002250) (Arg100- Leu233L) was expressed, with a polyhistidine tag at the N-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von NKG2A / CD159A / KLRC1 Protein

Purity	> 93 % as determined by SDS-PAGE	SDS-PAGE: NKG2A / CD159A / KLRC1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human human KLRC1 consists of 154 amino acids and predicts a molecular mass of 17.8 KDa. It migrates as an approximately 30-40 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von NKG2A / CD159A / KLRC1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von NKG2A / CD159A / KLRC1 Protein

NKG2, also known as NKG2A(CD159A), contains 1 C-type lectin domain and belongs to the killer cell lectin-like receptor family. The killer cell lectin-like receptor family is a group of transmembrane proteins preferentially expressed in NK cells. Members of this proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. NKG2 is expressed only in NK-cells, but not in T-cells or B-cells. It has been shown that NKG2 represents a family of related cDNA clones, designated NKG2A, NKG2B, NKG2C, and NKG2D, which encode type 2 integral membrane proteins (extracellular C-terminus) containing a C-type lectin domain. NKG2 forms a complex with another family member, KLRD1/CD94. NKG2A and NKG2B appear to be splice variants of the same gene and have been given the designation CD159a in the nomenclature of CD antigens. NKG2 plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

References

Angelini DF et al., 2011, J Leukoc Biol. 89(1):75-84.
Ge SJ et al., 2011, Zhongguo Shi Yan Xue Ye Xue Za Zhi. 19(2):312-6.
Ablamunits V et al., 2011, Eur J Immunol. 41(7):1832-42.

Sino Biological Inc. liefert NKG2A / CD159A / KLRC1 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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