MSLN / Mesothelin Protein

08.10.2012

Produkt-Information von MSLN / Mesothelin Protein

Synonym	MSLN, MPF
Protein Construction	A DNA sequence encoding the human MSLN (Q13421-2) (Met1-Arg286 ) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von MSLN / Mesothelin Protein

Purity	> 99 % as determined by SDS-PAGE	SDS-PAGE: MSLN protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Leu 37
Molecular Mass	The recombinant human MSLN/Fc comprises 491 amino acids and has a predicted molecular mass of 53.7 kDa. The apparent molecular mass of the protein is approximately 56 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von MSLN / Mesothelin Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von MSLN / Mesothelin Protein

Megakaryocyte potentiating factor is a member of the mesothelin family. This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Both megakaryocyte potentiating factor and the cleaved form of mesothelin are N-glycosylated. Mesothelin is a tumour differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum and pericardium. Megakaryocyte potentiating factor is secreted by several mesothelioma cell lines and is frequently elevated in the blood of patients with mesothelioma. Measurement of this protein may be useful in following the response of mesothelioma to treatment. Megakaryocyte potentiating factor interacts with MUC16 and potentiates megakaryocyte colony formation in vitro. Its membrane-anchored forms may play a role in cellular adhesion.

References

Chang MC. et al., 2012, Biochem J. 442 (2): 293-302.
Nelson HH. et al., 2011, Epigenetics. 6 (8): 1029-34.
Bournet B. et al., 2012, Pancreatology. 12 (1): 27-34.

Sino Biological Inc. liefert MSLN / Mesothelin Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über MSLN / Mesothelin Protein lesen Sie bitte: http://www.sinobiological.com/MSLN-Mesothelin-Protein-g-9335.html

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
MSLN / Mesothelin	Human	MSLN / Mesothelin (aa 296-580) Protein, Recombinant	13128-H01H
MSLN / Mesothelin	Human	MSLN / Mesothelin Protein, Recombinant	13128-H02H
MSLN / Mesothelin	Human	MSLN / Mesothelin Protein, Recombinant	13128-H08H