Mouse VNN1 / Vanin-1 Protein

Produkt-Information von VNN1 / Vanin-1 Protein

QC Testing von VNN1 / Vanin-1 Protein

Purity	> 96 % as determined by SDS-PAGE	SDS-PAGE VNN1 / Vanin-1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Leu 22
Molecular Mass	The secreted recombinant mouse VNN1/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 705 amino acids and has a calculated molecular mass of 79 kDa. As a result of glycosylation, the apparent molecular mass of rmVNN1/Fc monomer is approximately 85-90 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

VNN1 / Vanin-1 Protein Usage Guide

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Beschreibung von VNN1 / Vanin-1 Protein

Pantetheinase, also known as Pantetheine hydrolase, Vascular non-inflammatory molecule 1, Vanin-1, and VNN1, is a cell membrane protein which belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 contains one CN hydrolase domain. It is widely expressed with higher expression in spleen, kidney and blood. It is overexpressed in lesional psoriatic skin. Vanin-1 is also a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress. Vanin-1 is expressed by enterocytes, and its absence limits intestinal epithelial cell production of proinflammatory signals. Vanin-1 regulates late adhesion steps of thymus homing under physiological, noninflammatory conditions. The early impact of vanin-1 deficiency on tumor induction was directly correlated to the amount of inflammation and subsequent epithelial proliferation rather than cell death rate. Vanin-1 molecule was shown to be involved in the control of thymus reconstitution following sublethal irradiation.

References

1. Aurrand-Lions M. et al.,1996, Immunity. 5 (5): 391- 405.
2. Grimmond S. et al., 2000, Hum Mol Genet 9 (10):1553-60.
3. Meghari S. et al., 2007, Eur J Immunol. 37 (1): 24-32.
4. Johnson KA. et al.,2008, Am J Pathol. 172 (2): 440-53.
5. Pouyet L. et al., 2010, Inflamm Bowel Dis. 16 (1): 96-104.

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