Mouse IL1R1 / CD121a Protein

Produkt-Information von IL1R1 / CD121a Protein

QC Testing von IL1R1 / CD121a Protein

Purity	> 92 % as determined by SDS-PAGE	SDS-PAGE: IL1R1 / CD121a protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Leu 20
Molecular Mass	The secreted recombinant mouse IL1R1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 560 amino acids and has a calculated molecular mass of 64.3 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 70 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

IL1R1 / CD121a Protein Usage Guide

Verwandte Produkte & Themen von IL1R1 / CD121a Protein

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>IL-1R1/CD121a

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1R1/CD121a

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-1 Superfamily and IL-1R/TLR Family>>IL-1R1/CD121a

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Other>>IL-1R1/CD121a

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>IL-1R1/CD121a

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>IL-1R1/CD121a

Beschreibung von IL1R1 / CD121a Protein

Interleukin 1 receptor, type I (IL1R1), also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor that belongs to the IL-1 receptor family. IL1R1 is a receptor for both interleukin alpha (IL1A) and interleukin beta (IL1B), and also associates with interleukin-1 receptor antagonist protein (IL-1RA). There are two distinct types of receptors that bind the pleiotropic cytokines IL1A and IL1B: the type I is an 80 kDa transmembrane protein expressed predominantly by T cells, fibroblasts, and endothelial cells and appears to mediate all the known IL-1 biological functions. However, the type a… receptor is a 68 kDa transmembrane protein with a short cytoplamic domain and serves as a decoy for IL-1. IL1R1 structurally consists of three C2-type I g-like domains and one TIR domain. As important mediators involved in many immune and inflammatory responses, the agonists IL1A and IL1B bind to IL1R1, leading to the signal transduction and activation of NF-kappa-B. Formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2 is indepensible for the signaling processes. Recombinant soluble form of IL1R1 is thus a potent antagonist of IL-1 function.

References

1. Reddy, S. A. et al., 1997, J. Biol. Chem. 272 : 29167-29173.
2. Huang, J. et al.,1997, Proc. Natl. Acad. Sci. U.S.A. 94: 12829-12832.
3. Vigers, G. P.A. et al., 1997, Nature. 386:190-194.
4. Schreuder, H. et al., 1997, Nature. 386:194-200.
5. Vigers, G.P.A. et al., 2000, J. Biol. Chem. 275: 36927-36933.

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