Mouse VDR / NR111 Protein (His Tag)

Produkt-Information von VDR / NR111 Protein

QC Testing von VDR / NR111 Protein

Purity	> 86 % as determined by SDS-PAGE	SDS-PAGE: NR111 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant mouse VDR consists of 432 amino acids and has a calculated molecular mass of 49.2 kDa. The recombinant protein migrates as an approximately 55 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 20mM Tris,500mM NaCl, pH 8.0, 10%glycerol. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von VDR / NR111 Protein

Verwandte Produkte & Themen von VDR / NR111 Protein

Signal Transduction>>Transcription Factor & Regulator>> VDR

Beschreibung von VDR / NR111 Protein

VDR(vitamin D(1,25- dihydroxyvitamin D3)receptor, Histidine-tagged) , also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is comprised by three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. VDR can be detected in the intestine, thyroid and kidney and has a vital role in calcium homeostasis. VDR functions as nuclear hormone receptor and mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. It regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. VDR also plays a central role in calcium homeostasis and functions as a receptor for the secondary bile acid lithocholic acid. Defects in VDR are the cause of rickets vitamin D-dependent type 2A. A disorder of vitamin D metabolism can cause severe rickets, hypocalcemia and secondary hyperparathyroidism.

References

1. Moore DD. et al., 2006, Pharmacol Rev. 58 (4): 742-59.
2. Szpirer J. et al., 1991, Genomics. 11 (1): 168-73.
3. Germain P. et al., 2006, Pharmacol Rev. 58 (4): 685-704.
4. Adorini L. et al., 2006, Curr Top Med Chem. 6 (12): 1297-301.
5. Luderer HF. et al., 2010, J Steroid Biochem Mol Biol. 121 (1-2): 314-6.

Sino Biological Inc. liefert Mouse VDR / NR111 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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