Mouse CDCP1 Protein

Produkt-Information von CDCP1 Protein

QC Testing von CDCP1 Protein

Purity	> 79 % as determined by SDS-PAGE	SDS-PAGE: CDCP1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ser 30
Molecular Mass	The recombinant mouse CDCP1 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 878 amino acids and has a predicted molecular mass of 98.8 kDa. The apparent molecular mass of the protein is approximately 117 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CDCP1 Protein

Verwandte Produkte & Themen von CDCP1 Protein

Cancer >>Cancer Biomarker>>CDCP1

Beschreibung von CDCP1 Protein

CDCP1 is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. CDCP1 is a key regulator of EGF/EGFR-induced cell migration. It may be a rational approach to inhibit progression of cancers driven by EGFR signaling including those resistant to anti-EGFR drugs because of activating mutations in the RAS/RAF/MEK/ERK pathway. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets.

References

1. Conze T. et al., 2003, Ann N Y Acad Sci. 996 (1): 222-6.
2. Hooper JD. et al., 2003, Oncogene. 22 (12): 1783-94.
3. Scherl-Mostageer M. et al., 2001, Oncogene. 20 (32): 4402-8.

Sino Biological Inc. liefert Mouse CDCP1 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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